Which drug is known to be associated with Red Man Syndrome?

• A. Ciprofloxacin
• B. Vancomycin
• C. Metronidazole
• D. Amoxicillin

Answer: (B)

Red Man Syndrome is a reaction that is commonly associated with the administration of Vancomycin, primarily when the drug is infused rapidly. This syndrome is characterized by symptoms such as flushing, rash, and pruritus, especially affecting the upper body and face. The cause of this reaction is linked to the release of histamines in response to the rapid infusion of the drug.

In contrast, the other drugs listed do not have a significant association with this particular syndrome. Ciprofloxacin, while effective as an antibiotic, is not known for causing histamine-related reactions. Metronidazole can cause its own set of side effects but is not linked to Red Man Syndrome. Amoxicillin, a penicillin-type antibiotic, may cause allergic reactions in some patients, but those reactions are different from the histamine response observed with Vancomycin. Therefore, Vancomycin is specifically associated with this syndrome due to its infusion characteristics and the body's histamine response.